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Mechanics and Function of Organs, Tissues and Cells > Research > Research and Clinical Dilemmas  

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Coronary Circulation – Research and Clinical Dilemmas

Mechanics and Function of Organs, Tissues and Cells

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Coronary Circulation – Research and Clinical Dilemmas

Despite decades of thorough research, important aspects of coronary flow remain unclear or controversial:
- How, and by which physical mechanisms, contracting myocardium affects coronary flow?
- Why are epicardial arteries more vulnerable to atherogenesis than intramyocardial ones?
- Why is the subendocardial tissue more vulnerable to ischemia and infarction than subepicardium?
- What is the nature of the flow in intramyocardial coronary vessels? What is the predictive potential of flow indices measured in the catheterization room, in terms of the patient’s risk of infarction.

We aim at illuminating and settling these questions and in so doing, impact clinical management of the coronary patient.

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