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Mechanics and Function of Organs, Tissues and Cells > Research > Arterial Mechanics  

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Micro-Structural Modeling of Arterial Mechanics

Mechanics and Function of Organs, Tissues and Cells

 

Micro-Structural Modeling of Arterial Mechanics

Mechanical properties of arteries have essential role in pulsatile blood flow and in determining the mechanical environment of arterial cells, to which they may react to produce biological remodeling of the vessel structure and properties. Alterations in the vessels’ structure and properties are associated with a number of vascular pathologies such as cerebral and aortic aneurysms (see upper-right panel) and vessel remodeling under hypertension and atherosclerosis.

Analysis of normal and pathological arterial function has to be based on reliable material law of arteries, in both the passive and active (autoregulation) states. Our group is developing modeling framework for such laws based on the vessel wall microscopic structure (mid and lower-right panels). This micro-mechanical approach is known to provide a most reliable response prediction tool and in addition, facilitates determination of the realistic micro-mechanical environment of the wall cells. To this end we are using published studies on the complex structure of the vessel wall in terms of its concentric lamellae, fiber networks and smooth muscle cells. Using advanced analytical techniques from the field of non-linear solid mechanics combined with high performance parallel computer platforms, we are building fully three-dimensional nonlinear material model. The model is validated against experimental data.

 

Schematic diagram of arterial wall micro-structure 



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