Mechanics and Function of Organs, Tissues and Cells

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3-D Network Reconstruction

Myocardial blood flow is heterogeneous, both spatially and temporally, and highly dependent on the branching pattern and 3-D geometry of the coronary vasculature. Hence any realistic coronary flow analysis must be based on an accurate description of the coronary network anatomy and geometrical structure. Based on statistical data of network morphometry we developed the first stochastic 3-D model of the coronary vasculature which spans the entire spectrum of the coronary arteries and veins down to the capillary level.

This large scale reconstruction is based on highly non-linear optimization using Simulated Annealing (SA) search carried out with high-performance computing resources. The integrative artero-venous anatomical 3-D model will serve as a platform for a realistic large-scale flow analysis of the coronary circulation.